Breaking news on lymphoma, leukemia
Inherited Risk Factors For Childhood Leukemia Are More Common In Hispanic Patients published
Tue, 31 Jan 2012 02:00:00 PST
Hispanic children are more likely than those from other racial and ethnic backgrounds to be diagnosed with acute lymphoblastic leukemia (ALL) and are more likely to die of their disease. Work led by St. Jude Children's Research Hospital scientists has pinpointed genetic factors behind the grim statistics...
Leukemia Cells Are "Bad To The Bone" published
Mon, 30 Jan 2012 00:00:00 PST
University of Rochester Medical Center researchers have discovered new links between leukemia cells and cells involved in bone formation, offering a fresh perspective on how the blood cancer progresses and raising the possibility that therapies for bone disorders could help in the treatment of leukemia. The research, led by graduate student Benjamin J. Frisch in the James P...
Removal And Storage Of Ovarian Tissue Enables Birth After Cancer Treatment published
Fri, 27 Jan 2012 02:00:00 PST
For the first time in Germany, a woman has given birth to a child after removal and preservation of tissue from one of her ovaries. This course of action was necessary to avoid infertility owing to chemo- and radiotherapy. Andreas Müller and his colleagues report the case in the current issue of Deutsches Arzteblatt International (Dtsch Arztebl Int 2012; 109[1-2]: 8-13)...
A Leukemia Drug Kills Cancerous T-Cells While Sparing Normal Immunity published
Fri, 27 Jan 2012 00:00:00 PST
Leukemic cutaneous T-cell lymphoma (L-CTCL) is a leukemia arising from T-cells, a type of white blood cell. This cancer can involve the skin and other organs, and patients often die within three years. Rachael A...
Breast Cancers And Leukemias Slowed By A Single Therapy published
Tue, 24 Jan 2012 03:00:00 PST
Targeting a single protein can help fight both breast cancers and leukemias, according to two reports published online in the Journal of Experimental Medicine. The single protein is HSP90, which acts as a chaperone to protect other proteins in the cell...
Quality Of Life Issues For Patients With Chronic Myeloid Leukemia published
Tue, 24 Jan 2012 01:00:00 PST
Although significant progress has been made in treating chronic myeloid leukemia, the disease cannot yet be eliminated in all patients, and that challenge must be addressed, states a commentary in CMAJ (Canadian Medical Association Journal).). Likening the journey to find a cure for chronic myeloid leukemia as a marathon, cancer expert Dr...
Inherited Mutation Links Exploding Chromosomes To Cancer published
Sat, 21 Jan 2012 00:00:00 PST
An inherited mutation in a gene known as the guardian of the genome is likely the link between exploding chromosomes and some particularly aggressive types of cancer, scientists at the European Molecular Biology Laboratory (EMBL), the German Cancer Research Centre (DKFZ) and the University Hospital, all in Heidelberg, Germany, have discovered...
In Acute Myeloid Leukemia Study Pinpoints And Plugs Mechanism Of Cancer Cell Escape published
Fri, 20 Jan 2012 01:00:00 PST
A study published this week in the journal Leukemia identifies a mechanism that acute myeloid leukemia (AML) cells use to evade chemotherapy - and details how to close this escape route...
Potential New Approach For Treating Graft-Versus-Host-Disease Provided By Natural Enzyme published
Thu, 19 Jan 2012 00:00:00 PST
A natural enzyme derived from human blood plasma showed potential in significantly reducing the effects of graft-vs.-host disease, a common and deadly side effect of lifesaving bone marrow transplants. Researchers from the University of Michigan Comprehensive Cancer Center looked at the drug alpha-1-antitrypsin, which is approved by the U.S...
New Achilles Heel In Acute Myeloid Leukaemia Identified By Cell Death Researchers published
Wed, 18 Jan 2012 02:00:00 PST
Melbourne researchers have discovered that acute myeloid leukaemia (AML), an aggressive blood cancer with poor prognosis, may be susceptible to medications that target a protein called Mcl-1...
Study Published On Novel Treatment For Skin Lymphoma published
Wed, 18 Jan 2012 02:00:00 PST
Promising findings on a novel combination treatment approach for a chronic type of skin lymphoma are published in JAMA's Archives of Dermatology by clinical researchers from Seidman Cancer Center at University Hospitals (UH) Case Medical Center and Case Western Reserve University School of Medicine...
Newly Identified Genetic Alterations In T-ALL Provide New Potential Treatment Strategies For Devastating Childhood Leukemia published
Sun, 15 Jan 2012 00:00:00 PST
A new study published in the journal Nature Medicine by NYU Cancer Institute researchers, shows how the cancer causing gene Notch, in combination with a mutated Polycomb Repressive Complex 2 (PRC2) protein complex, work together to cause T- cell acute lymphoblastic leukemia (T-ALL). T-ALL is an aggressive blood cancer, predominately diagnosed in children...
Potential Approaches To Combat Aggressive Leukemia Identified By Cancer Sequencing Project published
Fri, 13 Jan 2012 00:00:00 PST
St...
Leukemia Relapse May Be Influenced By Chemotherapy published
Fri, 13 Jan 2012 00:00:00 PST
The chemotherapy drugs required to push a common form of adult leukemia into remission may contribute to DNA damage that can lead to a relapse of the disease in some patients, findings of a new study suggest. The research, by a team of physicians and scientists at Washington University School of Medicine in St. Louis, is published in the advance online edition of Nature...
Major Advance In Understanding The Regulation Of An Important Cancer Target published
Thu, 12 Jan 2012 00:00:00 PST
Scientists at the University of Leicester have opened up a whole new approach to the therapeutic intervention for a family of anti-cancer drug targets, thanks to a completely new and unexpected finding...
Protein Inhibitor Has Potent Anti-Tumor Effects, May Offer More Effective Treatment For Multiple Myeloma published
Wed, 11 Jan 2012 01:00:00 PST
A new study from SUNY Downstate Medical Center in Brooklyn, New York, shows that MAL3-101, a recently developed inhibitor of the heat shock protein 70 (Hsp70), appears to have potent anti-tumor effects on multiple myeloma, a bone marrow cancer. Despite aggressive modes of treatments, myeloma ultimately remains incurable. The disease has a high incidence in the communities served by SUNY Downstate...
News From The Journal Of Clinical Investigation: Jan. 9, 2012 published
Tue, 10 Jan 2012 01:00:00 PST
ONCOLOGY: KRAS provides maintenance for pancreatic cancer The outlook for individuals diagnosed with the most common form of pancreatic cancer, pancreatic ductal adenocarcinoma (PDA), is very poor; the average time of survival after diagnosis is less than 6 months. New therapeutic approaches are therefore much needed...
Fish Oil May Hold Key To Leukemia Cure published
Tue, 03 Jan 2012 00:00:00 PST
A compound produced from fish oil that appears to target leukemia stem cells could lead to a cure for the disease, according to Penn State researchers...
Transcriptional Elongation Control Takes On New Dimensions As Stowers Researchers Find Gene Class-Specific Elongation Factors published
Tue, 03 Jan 2012 00:00:00 PST
Life is complicated enough, so you can forgive the pioneers of DNA biology for glossing over transcriptional elongation control by RNA polymerase II, the quick and seemingly bulletproof penultimate step in the process that copies the information encoded in our DNA into protein-making instructions carried by messenger RNA. In a new report appearing in the Dec...
Autologous Stem Cell Transplantation Does Not Improve Overall Survival In Patients With Follicular Lymphoma published
Mon, 02 Jan 2012 00:00:00 PST
High-dose chemotherapy and autologous stem cell transplantation (HDC-ASCT), for previously untreated patients with advanced follicular lymphoma (FL) does not improve overall survival compared with conventional-dose chemotherapy alone, according to an online study published December 21 in the Journal of the National Cancer Institute...
Key Genetic Error Found In Family Of Blood Cancers published
Thu, 29 Dec 2011 00:00:00 PST
Scientists have uncovered a critical genetic mutation in some patients with myelodysplastic syndromes - a group of blood cancers that can progress to a fatal form of leukemia. The research team at Washington University School of Medicine in St. Louis also found evidence that patients with the mutation are more likely to develop acute leukemia...
Promising Treatments For Blood Cancers Presented By JT Cancer Center Researchers At ASH Meeting published
Wed, 28 Dec 2011 00:00:00 PST
Researchers from the John Theurer Cancer Center at Hackensack University Medical Center, one of the nation's top 50 best hospitals for cancer, presented results from 31 major studies of blood-related cancers - leukemia, lymphoma and multiple myeloma -- during the American Society of Hematology (ASH) Annual Meeting, December 10-13, 2011 in San Diego...
Presentations Highlight Results Of Clinical Data For MLN8237 And VELCADE® In The Treatment Of Lymphoma published
Fri, 23 Dec 2011 01:00:00 PST
Millennium: The Takeda Oncology Company with its parent company Takeda Pharmaceutical Company Limited (TSE:4502) reported the presentation of results from a phase 2 trial evaluating MLN8237, an investigational inhibitor of Aurora A kinase, in patients with aggressive B-cell and T-cell non-Hodgkin lymphoma (NHL)...
Key Genetic Mutations In Family Of Blood Cancers published
Tue, 20 Dec 2011 05:00:00 PST
A study published online in Nature Genetics reveals that scientists at the Washington University School of Medicine in St. Louis have uncovered a critical genetic mutation in some patients with myelodysplastic syndromes, which is are blood cancers that can progress to a fatal form of leukemia...
Multiple Myeloma Phase III Trial - Vorinostat Achieved Primary Endpoint published
Tue, 20 Dec 2011 05:00:00 PST
MSD announced the results of their Phase III study of vorinostat at the 53rd Annual Meeting of the American Society of Hematology (ASH)...
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