Breaking news on lung cancer
A New Genetic Subtype Of Lung Cancer Defined published
Thu, 02 Feb 2012 01:00:00 PST
A report from investigators at the Massachusetts General Hospital (MGH) Cancer Center has defined the role of a recently identified gene abnormality in a deadly form of lung cancer. Tumors driven by rearrangements in the ROS1 gene represent 1 to 2 percent of non-small-cell lung cancers (NSCLC), the leading cause of cancer death in the U.S...
News From The Journal Of Clinical Investigation: Feb. 1, 2012 published
Thu, 02 Feb 2012 01:00:00 PST
ONCOLOGY: Answers to age-old questions surrounding fat cell cancer Myxoid round cell liposarcoma (MRCLS) is a cancerous tumor that typically arises in deep fat tissues of the limbs or abdomen. It was shown almost 20 years ago to be characterized by a chromosomal change that generates a fusion protein known as TLS:CHOP...
Immunological Mechanisms Of Oncolytic Adenoviral Therapy published
Tue, 31 Jan 2012 00:00:00 PST
Cancer is one of the most common causes of death in humans. The conventional cancer therapies include surgery, radiotherapy, chemotherapy, and targeting therapies, which are intended to directly destroy and eliminate tumor cells. These treatments often fail, resulting in tumor metastasis and recurrence. Therefore, there is a critical need for novel cancer therapies...
New Drug Release Mechanism Developed That Utilizes 3D Superhydrophobic Materials published
Tue, 31 Jan 2012 00:00:00 PST
According to a recent study, there is a new mechanism of drug release using 3D superhydrophobic materials that utilizes air as a removable barrier to control the rate at which drug is released. The study was electronically published in the Journal of the American Chemical Society...
Lung Tumor Gene Test Predicts Surgery Outcomes published
Fri, 27 Jan 2012 12:00:00 PST
An assay which measures the activity of 14 genes in lung cancer tumors can accurately predict who will respond well to surgery and who will probably die within five years, researchers from the University of California, San Francisco, reported in The Lancet...
Smokers Continue Habit After Being Diagnosed With Cancer published
Tue, 24 Jan 2012 10:00:00 PST
According to a study published January 23 online in Cancer, many smokers do not drop the habit after being diagnosed with colorectal or lung cancer. The study by Elyse R. Ph.D., M.P.H.and her team at Massachusetts General Hospital, Boston involved 3,063 patients with colorectal cancer and 2,456 with lung cancer. The patients were seen at the time of diagnosis, and also five months later...
After A Cancer Diagnosis, Many People Continue To Smoke published
Tue, 24 Jan 2012 04:00:00 PST
A new analysis has found that a substantial number of lung and colorectal cancer patients continue to smoke after being diagnosed. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study provides valuable information on which cancer patients might need help to quit smoking...
Mechanism Of Lung-Cancer Drug Resistance Revealed By Study published
Mon, 23 Jan 2012 00:00:00 PST
New research published in Nature Medicine indicates that targeted drugs such as gefitinib might more effectively treat non-small cell lung cancer if they could be combined with agents that block certain microRNAs. The study was led by investigators with the Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J...
Study Examines Drug Resistance In ALK Positive Lung Cancer published
Fri, 20 Jan 2012 01:00:00 PST
Scientists from the University of Colorado Cancer Center have once again advanced the treatment of a specific kind of lung cancer. The team has documented how anaplastic lymphoma kinase (ALK) positive advanced non-small cell lung cancer (NSCLC) becomes resistant to a drug targeting the abnormal protein in the cancer...
TB And A Gene Mutation That Causes Lung Cancer Linked published
Thu, 19 Jan 2012 01:00:00 PST
Tuberculosis (TB) has been suspected to increase a person's risk of lung cancer because the pulmonary inflammation and fibrosis can induce genetic damage. However, direct evidence of specific genetic changes and the disease have not been extensively reported...
Early-Stage Non-Small Cell Lung Cancer - Malignancy Gene Signature Found published
Thu, 12 Jan 2012 09:00:00 PST
According to an investigation published in the recent issue of the Journal of the National Cancer Institute, researchers at Moffitt Cancer Center in Tampa, Florida have discovered that a malignancy-risk gene signature created for breast cancer has predictive and prognostic value for individuals suffering with early stage non-small cell lung cancer (NSCLC)...
Identification Of Precancer Markers In Airway Epithelium Cells Of Healthy Smokers published
Wed, 11 Jan 2012 01:00:00 PST
Smoking may be associated with the development of molecular features of cancer in the large airway epithelium. In the small airway epithelium, molecular cancerization is associated with development of chronic obstructive pulmonary disease, according to recent data...
As Monotherapy And In Combinations, Ganetespib Showed Activity In KRAS-Mutant NSCLC published
Wed, 11 Jan 2012 01:00:00 PST
The investigational drug ganetespib, a synthetic second-generation Hsp90 inhibitor, slowed the growth of cancer cells taken from non-small cell lung cancer tumors with a mutation in the KRAS gene. The drug was even more active when combined with traditional lung cancer treatments and other investigational targeted therapies, according to preclinical study data. David A. Proia, Ph.D...
Circulating Tumor Cells Analyzed In Patients With Lung Cancer published
Tue, 10 Jan 2012 02:00:00 PST
Researchers have developed a method to analyze circulating tumor cells in the blood of patients with non-small cell lung cancer. This method, which can analyze a sample size as small as three cells, may allow clinicians to track cancer progress and treatments and could help them develop new therapies...
Potential Genetic Origins, Pathways Of Lung Cancer In Never-Smokers, Mapped By Researchers published
Tue, 10 Jan 2012 01:00:00 PST
Researchers have begun to identify which mutations and pathway changes lead to lung cancer in never-smokers - a first step in developing potential therapeutic targets. Never-smokers (defined as an individual who smoked fewer than 100 cigarettes in his or her lifetime) are estimated to account for 10 percent of lung cancer cases...
Genetic Composition Of Multicentric Lung Tumors Appears To Be Similar published
Tue, 10 Jan 2012 01:00:00 PST
Multicentric carcinogenesis with the same genetic mutation appears to occur in lung adenocarcinoma, according to data presented at the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer: Biology, Therapy and Personalized Medicine, held Jan. 8-11, 2012...
Lung Cancer Prevention Potential For Estrogen-Targeting Drug Combo published
Tue, 10 Jan 2012 01:00:00 PST
A combination of drugs that target estrogen production significantly reduced the number of tobacco carcinogen-induced lung tumors in mice, according to results from a preclinical study. "Antiestrogens have been shown to prevent breast cancer in some women," said Jill M. Siegfried, Ph.D...
Sorafenib Effective In Patients With Non-small Cell Lung Cancer, But Low Survival Rates Reported published
Tue, 10 Jan 2012 01:00:00 PST
Sorafenib was effective in patients with non-small cell lung cancer and a KRAS mutation, but survival rates were reportedly "unsatisfactory," according to data presented at the AACR-IASLC Joint Conference on Molecular Origins of Lung Cancer: Biology, Therapy and Personalized Medicine, held Jan. 8-11, 2012...
Researchers Find Malignancy-Risk Gene Signature For Early-Stage Non-Small Cell Lung Cancer published
Tue, 10 Jan 2012 00:00:00 PST
A malignancy-risk gene signature developed for breast cancer has been found to have predictive and prognostic value for patients with early stage non-small cell lung cancer. The advancement was made by researchers at Moffitt Cancer Center in Tampa, Fla., who published their study results in a recent issue of the Journal of the National Cancer Institute...
Smokers Taking Statins May Be At Increased Risk Of Interstitial Lung Abnormalities published
Tue, 10 Jan 2012 00:00:00 PST
Use of statins may influence susceptibility to or the progression of interstitial lung disease (ILD) in smokers, according to a new study...
Custirsen Shows Promise For Advanced Non-small Cell Lung Cancer published
Fri, 06 Jan 2012 09:00:00 PST
Data assessing custirsen (OGX-011/TV-1011), an investigational compound, in individuals with advanced non-small cell lung cancer (NSCLC) were published online in the January 2012 issue of the Journal of Thoracic Oncology, OncoGenex Pharmaceuticals, Inc. announced January 4th...
New Test For Lung Cancer Screening Planned published
Wed, 04 Jan 2012 08:00:00 PST
Each year in the U.S., lung cancer kills more individuals than prostate, colon, and breast cancers combined. Often the disease goes undetected until it has reached an advanced and more difficult-to-treat stage. At present the only method to detect lung cancer are biopsies, which are highly involved and invasive for patients...
Gene Fusion In Lung Cancer Afflicting Never-Smokers May Be Target For Therapy published
Tue, 03 Jan 2012 00:00:00 PST
Smoking is a well-known risk factor for lung cancer, but nearly 25% of all lung cancer patients have never smoked. In a study published online in Genome Research (http://www.genome.org), researchers have identified a previously unknown gene fusion event that could explain a significant proportion of lung cancer cases in never-smokers, and might serve as a target for new therapies...
Roswell Park Researcher Aims To Develop Screening Test For Lung Cancer published
Sun, 01 Jan 2012 00:00:00 PST
Lung cancer takes a heavy toll, contributing to more cancer deaths in the United States each year than breast, prostate and colon cancers combined. Contributing to this poor prognosis is the fact that lung cancer often goes undetected until the disease has reached an advanced and more difficult-to-treat stage...
Lung Cancer Alliance Calls 2011 "The Turning Point" published
Sun, 01 Jan 2012 00:00:00 PST
Lung Cancer Alliance (LCA) President Laurie Fenton-Ambrose predicted that because of major breakthroughs this year in screening, treatment and research, 2011 will be defined as the turning point year for lung cancer...
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