Breaking news on liver disease, hepatitis
Hepatitis Research May Benefit From Stem Cells published
Fri, 03 Feb 2012 11:00:00 PST
Hepatitis C is a viral disease that leads to inflammation and organ failure. However, researchers are puzzled as to why some individuals are very susceptible to the disease, while others are not. Researchers believe they could find out how genetic variations produce these different responses by investigating liver cells from different individuals in the lab...
Stem Cells Could Drive Hepatitis Research Forward published
Fri, 03 Feb 2012 01:00:00 PST
Hepatitis C, an infectious disease that can cause inflammation and organ failure, has different effects on different people. But no one is sure why some people are very susceptible to the infection, while others are resistant. Scientists believe that if they could study liver cells from different people in the lab, they could determine how genetic differences produce these varying responses...
Recommendations For HPV And Hepatitis B Vaccinations Broadened By 2012 Adult Immunization Schedule published
Thu, 02 Feb 2012 01:00:00 PST
The CDC's Advisory Committee on Immunization Practices (ACIP) now recommends routine HPV vaccination for males aged 11 to 12 years and catch-up vaccination for males aged 13 to 21. These are just two of the changes to the 2012 Recommended Adult Immunization Schedule published February 1 in Annals of Internal Medicine, the flagship journal of the American College of Physicians (ACP)...
Shedding Light On Nonalcoholic Fatty Liver Disease: Gene Mutation Linked To Accumulation Of Fat, Other Lipids In Liver published
Thu, 02 Feb 2012 00:00:00 PST
A team of scientists from the University of Utah and the University of California at San Francisco has discovered that the mutation of a gene encoding a ketone body transporter triggers accumulation of fat and other lipids in the livers of zebrafish. This discovery, published in the Feb...
Post-Liver Transplantation Survival May Be Predicted By Cardiopulmonary Exercise Testing published
Wed, 01 Feb 2012 01:00:00 PST
Researchers from the U.K. determined that preoperative cardiopulmonary exercise testing (CPET) is a specific predictor of 90-day survival following liver transplantation...
New Information In The Fight Against Flu published
Tue, 31 Jan 2012 00:00:00 PST
Influenza virus can rapidly evolve from one form to another, complicating the effectiveness of vaccines and anti-viral drugs used to treat it...
Researchers Discover New Therapeutic Target To Combat Liver Cancer published
Sat, 28 Jan 2012 00:00:00 PST
Researchers at CIC Biogune, the Cooperative Centre for Research into Biosciences and led by Dr. Maria Luz Martinez Chantar, have found a strong relationship between high levels of Hu antigen R (HuR) protein and the malignancy of Hepatocellular Carcinoma, through a novel molecular process in the investigation of this pathology and known as neddylation...
Live Liver Donations Confirmed As Safe published
Fri, 27 Jan 2012 09:00:00 PST
According to Johns Hopkins researchers, individuals who donate a portion of their liver for live transplantation usually recover safely from the procedure and can expect to live long, healthy lives. The study is published in the February issue of the journal Gastroenterology. Dorry L. Segev, M.D., Ph.D...
Identification Of Entry Point For Hepatitis C Infection published
Thu, 26 Jan 2012 00:00:00 PST
A molecule embedded in the membrane of human liver cells that aids in cholesterol absorption also allows the entry of hepatitis C virus, the first step in hepatitis C infection, according to research at the University of Illinois at Chicago College of Medicine...
Many High-Risk Americans Don't Get Hepatitis B Vaccine published
Sun, 22 Jan 2012 00:00:00 PST
A recently published study investigating hepatitis B vaccination rates in the United States found that more than half of adults at risk for hepatitis B virus remain unvaccinated. With many of these individuals making contact with the healthcare system, including HIV testing, this statistic reflects many missed opportunities to vaccinate this population...
Small Changes In The Genome Account For Gender Differences In Liver Cancer Risk published
Sat, 21 Jan 2012 00:00:00 PST
Men are four times more likely to develop liver cancer compared to women, a difference attributed to the sex hormones androgen and estrogen. Although this gender difference has been known for a long time, the molecular mechanisms by which estrogens prevent - and androgens promote - liver cancer remain unclear...
Common Type Of Hepatitis C Suppressed By Combination Of Oral Drugs published
Fri, 20 Jan 2012 01:00:00 PST
A new combination of investigational drugs successfully suppressed hepatitis C genotype 1 infection in a high percent of patients who had not responded to previous treatment in a study led by a University of Michigan hepatologist. The study, which was published Jan...
Researchers Identify Modifiable Risk Factors That Could Limit The Incidence Of Post-Transplant End-Stage Renal Disease published
Thu, 19 Jan 2012 01:00:00 PST
Research from the University of Michigan Health System shows the risk for kidney failure among liver transplant recipients is higher following the implementation of Model of End Stage Liver Disease (MELD), a policy change in 2002 that altered how liver transplant allocation is decided. The study, led by Pratima Sharma, M.D., M.S...
News From The Journal Of Clinical Investigation: Jan. 17, 2012 published
Wed, 18 Jan 2012 02:00:00 PST
VIROLOGY: How to prevent hepatitis B virus reproducing Infection with hepatitis B virus (HBV) is a major health problem worldwide, despite the fact that a highly effective preventative vaccine exists. A modified form of the immune molecule IFN-alpha is commonly used to treat individuals infected with HBV...
Pediatric Liver Transplant Graft Recipients Can Stay Off Immunosuppressant Medications published
Tue, 17 Jan 2012 13:00:00 PST
A study in the January 18 issue of JAMA reveals that the majority of children who received liver transplant grafts from a parent were able to stay off immunosuppression therapy for at least 1 year with normal graft function after gradual withdrawal from the therapy...
Potential New Therapy Approach For Hepatitis C Could Benefit 170 Million People Affected Worldwide published
Tue, 17 Jan 2012 02:00:00 PST
Researchers at the University of British Columbia have found a new way to block infection from the hepatitis C virus (HCV) in the liver that could lead to new therapies for those affected by this and other infectious diseases. More than 170 million people worldwide suffer from hepatitis C, the disease caused by chronic HCV infection...
Blocking Cell-To-Cell Communication May Prevent Liver Damage And Improve Drug Safety published
Tue, 17 Jan 2012 00:00:00 PST
Massachusetts General Hospital (MGH) investigators have developed a novel strategy to protect the liver from drug-induced injury and improve associated drug safety...
Older Americans With Cirrhosis Suffer High Rates Of Disability published
Thu, 12 Jan 2012 01:00:00 PST
Older patients with cirrhosis have significant functional disability, require twice the amount of informal caregiving, and contribute added strain on the health care system, according to U-M research published in Hepatology. Given the increase in obesity and aging of those with hepatitis C (HCV), researchers expect the prevalence of cirrhosis to climb among older Americans....
New Fibrosis Classification Improves Accuracy Of Diagnosis In Hepatitis C published
Thu, 12 Jan 2012 01:00:00 PST
A new classification for diagnosing fibrosis in patients with chronic hepatitis C virus (HCV) has shown to be as accurate as currently used algorithms, but required no further liver biopsy...
Genetic And Mechanistic Basis For Rotor Syndrome Uncovered published
Tue, 10 Jan 2012 01:00:00 PST
The main symptom of Rotor syndrome is jaundice caused by a buildup of a substance known as conjugated bilirubin. Bilirubin is a yellow substance generated in large quantities when the body recycles red blood cells. It is conjugated in the liver to make it soluble in water so that it can be cleared from the body...
Hep C Vaccine Shows Promise In First Trial published
Sat, 07 Jan 2012 00:00:00 PST
An experimental vaccine against the chronic liver disease hepatitis C has shown promising results in its first clinical trial in humans, say researchers from the University of Oxford, UK, who write about their findings in the 4 January online issue of Science Translational Medicine...
Treating Liver Cancer With Antisense Oligonucleotide published
Thu, 05 Jan 2012 01:00:00 PST
A new study shows that it is possible to selectively target and block a particular microRNA that is important in liver cancer. The finding might offer a new therapy for this malignancy, which kills an estimated 549,000 people worldwide annually. The animal study, by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J...
For Children With Rare Disease, Maternal Liver Grafts More Tolerable published
Thu, 05 Jan 2012 00:00:00 PST
Results may have important implications for counseling parents on organ donation Children with a rare, life-threatening disease that is the most common cause of neonatal liver failure - biliary atresia - better tolerate liver transplants from their mothers than from their fathers, according to a UCSF-led study...
Mayo Clinic Studies Identify Risk Factors In Rising Trend Of Liver Cancer published
Wed, 04 Jan 2012 01:00:00 PST
Doctors have known for years that the incidence of deadly liver cancer is on the rise, but what is causing that trend has remained a mystery. Two recent Mayo Clinic studies published in the January issue of Mayo Clinic Proceedings offer a clearer picture of the rise of hepatocellular carcinoma (HCC), or liver cancer, which has tripled in the U.S...
Mechanism Explains How Hepatitis C Virus Survives In The Liver And How A New Antiviral Works published
Tue, 03 Jan 2012 01:00:00 PST
Viral diseases are still one of the biggest challenges to medical science. Thanks to thousands of years of co-evolution with humans, their ability to harness the biology of their human hosts to survive and thrive makes them very difficult to target with medical treatment...
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