Breaking news on huntingtons disease
Stem Cells Show Promise For Delivering Gene Therapy For Huntington's Disease published
Tue, 24 Jan 2012 00:00:00 PST
A team of researchers at the UC Davis Institute for Regenerative Cures has developed a technique for using stem cells to deliver therapy that specifically targets the genetic abnormality found in Huntington's disease, a hereditary brain disorder that causes progressive uncontrolled movements, dementia and death...
Circadian Rhythm Disruption Causes Neurodegeneration, Early Death published
Thu, 12 Jan 2012 00:00:00 PST
New research at Oregon State University provides evidence for the first time that disruption of circadian rhythms - the biological "clocks" found in many animals - can clearly cause accelerated neurodegeneration, loss of motor function and premature death. The study was published in Neurobiology of Disease and done by researchers at OSU and Oregon Health and Science University...
Studies Identify Promising Genes And Small Molecules To Use Against Devastating Diseases published
Mon, 09 Jan 2012 00:00:00 PST
Two related studies from Northwestern University offer new strategies for tackling the challenges of preventing and treating diseases of protein folding, such as Alzheimer's, Parkinson's and Huntington's diseases, amyotrophic lateral sclerosis (ALS), cancer, cystic fibrosis and type 2 diabetes. To do its job properly within the cell, a protein first must fold itself into the proper shape...
In Huntington's Disease, Regulatory Enzyme Overexpression May Protect Against Neurodegeneration published
Fri, 30 Dec 2011 00:00:00 PST
Treatment that increases brain levels of an important regulatory enzyme may slow the loss of brain cells that characterizes Huntington's disease (HD) and other neurodegenerative disorders...
Researchers Slow Progression Of Huntington's Disease In Mouse Models published
Mon, 19 Dec 2011 01:00:00 PST
Working with genetically engineered mice, Johns Hopkins researchers have discovered that a gene (SIRT1) linked to slowing the aging process in cells also appears to dramatically delay the onset of Huntington's disease (HD) and slow the progression of the relentless neurodegenerative disorder...
New Drug That Improves Memory And Prevents Brain Damage In Mice May Prevent Alzheimer's Disease Progression published
Thu, 15 Dec 2011 07:00:00 PST
A new drug candidate may be the first capable of halting the devastating mental decline of Alzheimer's disease, based on the findings of a study published in PLoS one. When given to mice with Alzheimer's, the drug, known as J147, improved memory and prevented brain damage caused by the disease...
Study Identifies Most Effective Ways To Assess Progression In Huntington's Disease, Which Could Speed Up Development Of Disease-modifying Drugs published
Fri, 02 Dec 2011 09:00:00 PST
Researchers have identified a set of objective, validated measures for evaluating new treatments for Huntington's disease (HD) in phase 2 and 3 clinical trials. According to the researchers, whose findings have been published Online first in The Lancet Neurology, the discovery should increase future new drug trial's chances of success to delay onset and reduce the severity of HD...
Newly Established Neuroscience Clinical Trials Center Could Bring Treatments To Patients Faster published
Fri, 02 Dec 2011 01:00:00 PST
In a development that could pave the way for treatment for rare neurological diseases and clues to more common ones, physician-scientists at Albert Einstein College of Medicine of Yeshiva University and Montefiore Medical Center, the University Hospital for Einstein, have secured a grant to establish a clinical site for the Network for Excellence in Neuroscience Clinical Trials (NeuroNEXT)...
In Mouse Model Dantrolene Protects Neurons From Huntington's Disease published
Mon, 28 Nov 2011 00:00:00 PST
Huntington's disease (HD) is characterized by ongoing destruction of specific neurons within the brain. It affects a person's ability to walk, talk, and think - leading to involuntary movement and loss of muscle co-ordination...
Huntington's Disease - Pridopidine Shows Promise In Trial published
Thu, 10 Nov 2011 05:00:00 PST
According to results of the phase 3 MermaiHD trial published Online First in The Lancet Neurology, a unique drug (pridopidine) that stabilizes dopamine signaling in areas of the brain controlling movement and coordination in patients with Huntington's disease (HD), a condition characterized by an imbalance in the signaling chemical dopamine, seems to be well tolerated and merit...
Protein Form Linked To Huntington's Disease Identified By Gladstone Scientists published
Tue, 01 Nov 2011 00:00:00 PST
Scientists at the Gladstone Institutes have discovered how a form of the protein linked to Huntington's disease influences the timing and severity of its symptoms, offering new avenues for treating not only this disease, but also a variety of similar conditions...
In Mouse Model Of Huntington's Disease, Melatonin Found To Delay Onset, Reduce Deaths published
Wed, 12 Oct 2011 03:00:00 PST
Melatonin, best known for its role in sleep regulation, delayed the onset of symptoms and reduced mortality in a mouse model of Huntington's disease, say researchers at the University of Pittsburgh School of Medicine and Harvard Medical School...
New Insight Into The Cellular Defects In Huntington's Disease published
Tue, 11 Oct 2011 03:00:00 PST
Huntington's disease is a devastating neurogenerative disorder that causes a progressive loss of functional capacity and reduced life span. It is an inherited condition caused by a mutant HTT gene...
Transcriptional Biomarker Identified That Could Help Monitor Huntington's Disease Activity, Evaluate Potential Treatments published
Tue, 04 Oct 2011 01:00:00 PST
Huntington's disease, a devastating genetic disorder that causes degeneration of nerve cells in the brain, affects more than 15,000 Americans, and at least 150,000 are at risk of developing the disease...
Candidate Therapeutic Target Provided By Link Between Aging And Huntington's Disease published
Tue, 20 Sep 2011 04:00:00 PST
Aging is a major risk factor for the progression of neurodegenerative diseases, including Huntington disease (HD). Morris White and colleagues, at Harvard Medical School, Boston, have now determined that modulating levels of the signaling protein Irs2 changes disease progression in a mouse model of HD...
Scientists Discover How Molecular Motors Go Into "Energy Save Mode" published
Mon, 15 Aug 2011 00:00:00 PST
The transport system inside living cells is a well-oiled machine with tiny protein motors hauling chromosomes, neurotransmitters and other vital cargo around the cell. These molecular motors are responsible for a variety of critical transport jobs, but they are not always on the go...
Scientist Converts Human Skin Cells Into Functional Brain Cells: Breakthrough Is Likely To Advance Medicine And Human Health published
Mon, 01 Aug 2011 00:00:00 PST
A scientist at the Gladstone Institutes has discovered a novel way to convert human skin cells into brain cells, advancing medicine and human health by offering new hope for regenerative medicine and personalized drug discovery and development...
New Evidence Of Age-Related Decline In The Brain's Master Circadian Clock published
Wed, 20 Jul 2011 00:00:00 PST
A new study of the brain's master circadian clock - known as the suprachiasmatic nucleus, or SCN - reveals that a key pattern of rhythmic neural activity begins to decline by middle age. The study, whose senior author is UCLA Chancellor Gene Block, may have implications for the large number of older people who have difficulty sleeping and adjusting to time changes...
AMPK Amplifies Huntington's Disease published
Tue, 19 Jul 2011 02:00:00 PST
A new study describes how hyperactivation of AMP-activated protein kinase (AMPK) promotes neurodegeneration in Huntington's disease (HD). The article appears online on July 18, 2011, in The Journal of Cell Biology. The aggregation of mutant Huntingtin protein in HD disrupts many cellular processes, including metabolism...
Compound May Provide Drug Therapy Approach For Huntington's Disease published
Fri, 24 Jun 2011 00:00:00 PST
UT Southwestern Medical Center researchers have identified compounds that appear to inhibit a signaling pathway in Huntington's disease, a finding that may eventually lead to a potential drug therapy to help slow the progression of degenerative nerve disorders...
A Key Trigger To A Rare But Deadly Neurodegenerative Disease Revealed By Molecular Biophysics Professor published
Thu, 23 Jun 2011 02:00:00 PST
Jeremy Smith, Governor's Chair for Molecular Biophysics at the University of Tennessee, Knoxville, has helped reveal a key trigger of Gerstmann-Sträussler-Scheinker (GSS) syndrome, a rare but deadly neurodegenerative disease. The finding could have far-reaching implications for the treatment of other neurodegenerative diseases such as Alzheimer's, Huntington's, and Parkinson's...
A Step Toward Controlling Huntington's Disease? published
Tue, 21 Jun 2011 10:00:00 PST
Johns Hopkins researchers have identified a natural mechanism that might one day be used to block the expression of the mutated gene known to cause Huntington's disease. Their experiments offer not an immediate cure, but a potential new approach to stopping or even preventing the development of this relentless neurodegenerative disorder...
Discovery Of Drug Candidate For Alzheimer's, Huntington's Disease published
Fri, 03 Jun 2011 02:00:00 PST
Scientists at the Gladstone Institutes have identified a drug candidate that diminishes the effects of both Alzheimer's disease and Huntington's disease in animal models, offering new hope for patients who currently lack any medications to halt the progression of these two debilitating illnesses...
Huntington's Disease Breakthrough Announced By Trans-Atlantic Team published
Fri, 03 Jun 2011 00:00:00 PST
Medical researchers may have uncovered a novel approach to treat an incurable and ultimately fatal neurodegenerative disease that affects hundreds of thousands of people...
Trans-Atlantic Team Announce Huntington's Disease Breakthrough published
Thu, 02 Jun 2011 09:00:00 PST
Medical researchers may have uncovered a novel approach to treat an incurable and ultimately fatal neurodegenerative disease that affects hundreds of thousands of people...
)
|
|
