Breaking news on huntingtons disease
Huntingtin Linked To Neurogenesis published
Fri, 13 Aug 2010 00:00:00 PDT
New research finds that a protein that is often mutated in Huntington's disease (HD) plays an unexpected role in the process of neurogenesis. The research, published by Cell Press in the August 12 issue of the journal Neuron, provides new insight into HD pathology and has even broader implications for human health and disease...
'Clumping Proteins' In Neurodegeneration Common In Aging Process published
Wed, 11 Aug 2010 03:00:00 PDT
Many proteins that form insoluble clumps in the brains of people with Alzheimer's and other neurodegenerative diseases are also found in healthy individuals and clump together as a normal part of aging. According to a surprising new finding by researchers at the University of California, San Francisco, the discovery in the C...
Levels And Efficacy Of A Marijuana-Like Substance In The Brain Controlled By Newly Discovered Mechanism published
Mon, 09 Aug 2010 00:00:00 PDT
A newly discovered molecular mechanism helps control the amount and effectiveness of a substance that mimics an active ingredient in marijuana, but that is produced by the body's own nerve cells. The results were reported in the latest Nature Neuroscience. The lead author on the study is William R. Marrs of the Neurobiology and Behavior program at the University of Washington (UW)...
Path That Stops Cells Consuming Themselves For Energy May Help Understanding Of Cancer And Aging published
Mon, 02 Aug 2010 02:00:00 PDT
US researchers have discovered a biological path that is essential for maintaining normal means of energy production in cells and may help us better understand metabolic processes in cancer and aging; cells use the path to shuttle calcium in and out of mitochondria, the tiny energy generators inside cells, and when it breaks down, cells consume themselves to get the energy they need...
New Pathway To Parkinson's And Alzheimer's Diseases published
Fri, 30 Jul 2010 01:00:00 PDT
Although their genetic underpinnings differ, Alzheimer's disease, Parkinson's disease and Huntington's disease are all characterized by the untimely death of brain cells...
Protease Associated With Damage After Stroke Implicated In Huntington's Toxicity published
Fri, 30 Jul 2010 00:00:00 PDT
A new study reveals that an enzyme linked with multiple disorders is also involved in the generation of toxic, neuron-killing protein fragments in Huntington's disease (HD). The research, published by Cell Press in the July 29 issue of Neuron, provides insight into Huntington's pathology and proposes new therapeutic strategies for this devastating incurable disease...
Discovery Provides New Hope For Huntington Disease Treatment published
Thu, 29 Jul 2010 05:00:00 PDT
Australian scientists have identified the behaviour of the mutant protein 'huntingtin' which leads to the fatal Huntington's disease providing potential targets to treat the disease, a University of Melbourne study reveals. Huntington's disease is a genetic disease with no cure, characterized by a steady decline in motor control and the dysfunction and death of brain cells...
Leap Forward In Efforts To Develop Treatments For Huntington's Disease published
Thu, 29 Jul 2010 01:00:00 PDT
Scientists at the Buck Institute for Age Research have discovered that a particular family of enzymes are involved in the breakdown of proteins that modify the production of toxic fragments that lead to the pathology of Huntington's disease...
Huntington's Disease Greatly Underestimated In The UK published
Sun, 25 Jul 2010 01:00:00 PDT
The prevalence of Huntington's disease (HD) is substantially underestimated in the UK, with significant implications for those affected, the healthcare system, and research...
UB Researchers Propose A Novel Therapeutic Target For The Treatment Of Huntington's Disease published
Sun, 25 Jul 2010 01:00:00 PDT
An article published in The Journal of Biological Chemistry presents a novel pharmacological target that, in combination with a neurotrophic factor, could be used to improve the survival of striatal neurons, the principal nerve cells affected by the neurodegeneration observed in Huntington's disease...
Every Action Has A Beginning And An End (And It's All In Your Brain) published
Thu, 22 Jul 2010 02:00:00 PDT
Rui Costa, Principal Investigator of the Champalimaud Neuroscience Programme at the Instituto Gulbenkian de Ciência (Portugal), and Xin Jin, of the National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health (USA), describe in the latest issue of the journal Nature, that the activity of certain neurons in the brain can signal the initiation and terminatio...
New PBT2 Data In 2010 Hot Topics Session At International Conference On Alzheimer's Disease published
Fri, 02 Jul 2010 01:00:00 PDT
Prana Biotechnology Limited (NASDAQ: PRAN) (ASX: PBT) announced that its Head of Research, Assoc. Prof. Robert Cherny, will present new data on PBT2, the Company's lead compound in development for Alzheimer's disease, at the Hot Topics Therapeutics/Intervention session on July 14th at the International Conference of Alzheimer's Disease (ICAD) in Honolulu...
Prevalence Of Huntington's Disease Much Higher Than Estimated published
Wed, 30 Jun 2010 02:00:00 PDT
Huntington's disease (HD) is much more common in the UK than current estimates suggest, according to a new Comment published in the peer-reviewed medical journal The Lancet. The Comment was written by Professor Sir Michael Rawlins, Chairman of the UK National Institute for Health and Clinical Excellence (NICE)...
Abnormal Protein Makes Huntington's Disease Patients Sick published
Wed, 16 Jun 2010 02:00:00 PDT
An aggregating protein causes many of the symptoms of Huntington's disease, an incurable and frequently fatal brain disorder. Mosaic winner Ahmad Aziz discovered that the abnormal protein also aggregates in the hypothalamus, the part of the brain that regulates the autonomic nervous system and the endocrine system...
Program Will Use Stem Cell Modeling And Genome Sequencing To Identify And Screen Potential Therapies For Huntington's Disease published
Wed, 16 Jun 2010 01:00:00 PDT
The Institute for Systems Biology (ISB) of Seattle, WA, is collaborating with the Gladstone Institute of Neurological Disease (GIND) and its Taube-Koret Center for Huntington's Disease Research to use whole-genome sequencing to identify genes and novel drug targets related to the onset and progression of Huntington's disease (HD)...
Scientists Make Important Step Toward Stopping Plaque-Like Formations In Huntington's Disease published
Sat, 22 May 2010 01:00:00 PDT
They might not be known for their big brains, but fruit flies are helping to make scientists and doctors smarter about what causes Huntington's disease and how to treat it...
Eventual Huntington's Drug May Have Clear Path To Affected Brain Region, Solomon Snyder Tells Pharmacy Students published
Wed, 05 May 2010 04:00:00 PDT
If a drug was developed to block a key protein linked to the onset of Huntington's Disease, it could have a clear path to the part of the brain most affected by the disease, while not bothering other parts of the brain and body, said distinguished neuroscientist Solomon H. Snyder, MD, to an audience of about 300 students and faculty at the University of Maryland, Baltimore (UMB)...
Eventual Huntington's Drug May Have Clear Path To Affected Brain Region, Solomon Snyder Tells Pharmacy Students published
Wed, 05 May 2010 02:00:00 PDT
If a drug was developed to block a key protein linked to the onset of Huntington's Disease, it could have a clear path to the part of the brain most affected by the disease, while not bothering other parts of the brain and body, said distinguished neuroscientist Solomon H. Snyder, MD, to an audience of about 300 students and faculty at the University of Maryland, Baltimore (UMB)...
In Huntington's Disease Ku70 Shown To Be Critical Regulator Of DNA Damage published
Tue, 04 May 2010 06:00:00 PDT
Ku70, a component of the DNA repair complex, is shown to be a new critical player in the DNA damage-linked pathologies of Huntington's disease (HD), according to a study in the May 3 issue of the Journal of Cell Biology. DNA repair defends against naturally occurring or disease-related DNA damage during the long lifespan of neurons...
Small Molecules Mimicking Key Brain Growth Factor Identified By Study published
Tue, 20 Apr 2010 02:00:00 PDT
Stanford University School of Medicine researchers have identified several small molecules that mimic a key but cumbersome protein in the brain, a discovery that could open the door to new therapies for a variety of brain disorders. The protein, designated by the acronym BDNF, is known to be involved in important brain functions that include memory and learning...
Huntington's Disease: Faulty Cleanup Process May Be Key Event In Cause published
Tue, 13 Apr 2010 04:00:00 PDT
In a step towards a possible treatment for Huntington's disease, scientists at Albert Einstein College of Medicine of Yeshiva University have shown for the first time that the accumulation of a mutated protein may explain damaging cellular behavior in Huntington's disease. Their research is described in the April 11 online edition of Nature Neuroscience...
Faulty Clean-up Process May Be Key Event In Huntington's Disease published
Mon, 12 Apr 2010 03:00:00 PDT
In a step towards a possible treatment for Huntington's disease, scientists at Albert Einstein College of Medicine of Yeshiva University have shown for the first time that the accumulation of a mutated protein may explain damaging cellular behavior in Huntington's disease. Their research is described in the April 11 online edition of Nature Neuroscience...
Long-Term Efficacy Of Xenazine® (Tetrabenazine) For The Treatment Of Chorea Associated With Huntington's Disease published
Mon, 08 Mar 2010 01:00:00 PDT
Lundbeck Inc. has announced the presentation of results from an open-label extension study of Xenazine® (tetrabenazine) for the treatment of chorea associated with Huntington's disease (HD)...
Protecting The Brain From A Deadly Genetic Disease published
Wed, 24 Feb 2010 01:00:00 PDT
Huntington's disease (HD) is a cruel, hereditary condition that leads to severe physical and mental deterioration, psychiatric problems and eventually, death. Currently, there are no treatments to slow down or stop it. HD sufferers are born with the disease although they do not show symptoms until late in life...
Drug Shows Promise For Huntington's Disease published
Tue, 09 Feb 2010 02:00:00 PDT
An early stage clinical trial of the experimental drug dimebon (latrepirdine) in people with Huntington's disease appears to be safe and may improve cognition. That is the conclusion of a study published in the Archives of Neurology...
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