Breaking news on cjd vcjd mad cow disease
New Sporadic Prion Protein Disease Identified By CWRU published
Sat, 14 Aug 2010 01:00:00 PDT
A new sporadic prion protein disease has been discovered. Variably protease-sensitive prionopathy (VPSPr), as it has been named, is the second type of complete sporadic disease to be identified since Creutzfeldt-Jakob disease (CJD) was reported in the 1920s...
Infectious Prions Can Arise Spontaneously In Normal Brain Tissue published
Wed, 28 Jul 2010 00:00:00 PDT
In a startling new study that involved research on both sides of the Atlantic, scientists from The Scripps Research Institute in Florida and the University College London (UCL) Institute of Neurology in England have shown for the first time that abnormal prions, bits of infectious protein devoid of DNA or RNA that can cause fatal neurodegenerative disease, can suddenly erupt fr...
Canadian Researchers Testing Unique Vaccines For Prion Diseases And Common Cancers published
Tue, 27 Jul 2010 07:00:00 PDT
Several Canadian researchers have come together to help control the relentless spread of a prion disease, chronic wasting disease (CWD) in deer and elk, through vaccines. At the same time they aim to generate safe and effective therapies for common cancers. This simultaneous research is possible thanks to a unique connection they have discovered between the two unrelated diseases...
Surgery Linked To Creutzfeldt-Jakob Disease published
Fri, 09 Jul 2010 02:00:00 PDT
A new study spearheaded by Spanish scientists demonstrates a causal relationship between the onset of Creutzfeldt-Jakob disease (CJD), caused by a protein called a prion, and general surgery. CJD manifests itself in hereditary acquired; and sporadic forms, or for unknown reasons, which accounts for the majority of cases...
In Prion Disease Transmission Sequence And Structure Is Key published
Tue, 15 Jun 2010 02:00:00 PDT
Prion diseases are lethal neurodegenerative disorders that include Creutzfeldt-Jakob disease (CJD) in humans and bovine spongiform encephalopathy (BSE; commonly known as mad cow disease) in cows...
Detecting CJD Through The Eyes Of Cattle published
Thu, 03 Jun 2010 06:00:00 PDT
The eyes may or may not be windows to the soul, as the old adage goes, but scientists are reporting evidence that a peek into the eyes of cattle may become the basis for a long-sought test to detect infection with the agent that causes Mad Cow Disease. That test could help prevent the disease from spreading in the food supply...
News From The American Journal Of Pathology published
Wed, 26 May 2010 06:00:00 PDT
Inflammasome Increases Muscle Damage in Muscular Dystrophy Dr. Kanneboyina Nagaraju and colleagues at the Children's National Medical Center, Washington, DC demonstrate that affected muscle may directly contribute to inflammation in muscular dystrophy. Their report can be found in the June 2010 issue of The American Journal of Pathology...
How Is Creutzfeldt-Jakob Disease (CJD) Transmitted? Can CJD Be Transmitted From Person To Person? published
Mon, 19 Apr 2010 00:00:00 PDT
Researchers have identified three basic ways that Creutzfeldt-Jakob disease (CJD) may develop: Spontaneously. Most people with classic CJD develop the disease for no apparent reason. CJD cases occurring without explanation are called spontaneous CJD or sporadic CJD. This is the great majority of all cases. Normally, sCJD affects people over 40 years of age. By genetic mutation...
How Is Creutzfeldt-Jakob Disease (CJD) Diagnosed? Diagnosing Creutzfeldt-Jakob Disease (CJD) published
Mon, 19 Apr 2010 00:00:00 PDT
Only a brain biopsy or an examination of brain tissue after death during autopsy can confirm (diagnose) the presence of Creutzfeldt-Jakob disease (CJD). However, doctors often can make an accurate diagnosis based on the patient's medical and personal history, a neurological exam, and certain diagnostic tests...
Chronix Biomedical Partners With University Of Calgary To Commercialize Serum DNA-Based Blood Test For Mad Cow Disease published
Thu, 15 Apr 2010 01:00:00 PDT
Chronix Biomedical today announced that it is partnering with the University of Calgary to develop a commercial version of its serum DNA-based blood test for the early detection of bovine spongiform encephalopathy (BSE), also known as mad cow disease...
The Assembly Of Protein Strands Into Fibrils published
Tue, 13 Apr 2010 05:00:00 PDT
The Atomic Force Microscope depicts on its screen the few nanometer thick and few micrometer long fibers as white flexible sticks, crisscrossing the surface on which they are deposited. The very peculiar property of these proteins lies in fact that they can self assemble into complex ribbon-like twisted fibers...
Scientists Find New Form Of Prion Disease That Damages Brain Arteries published
Sat, 06 Mar 2010 00:00:00 PDT
WHAT: National Institutes of Health (NIH) scientists investigating how prion diseases destroy the brain have observed a new form of the disease in mice that does not cause the sponge-like brain deterioration typically seen in prion diseases. Instead, it resembles a form of human Alzheimer's disease, cerebral amyloid angiopathy, that damages brain arteries...
Prestigious Dementia Research Honor For Two UCSF Scientists published
Sat, 20 Feb 2010 00:00:00 PDT
Two UCSF scientists have been selected for the American Academy of Neurology's prestigious Potamkin Prize, for their "outstanding achievements" in research on dementias. Bruce Miller, MD, W. & Mary Margaret Clausen Distinguished Professor of Neurology, and Lennart Mucke, MD, Joseph B...
Prion Protein In Cell Culture published
Sat, 06 Feb 2010 01:00:00 PDT
The fatal brain disease Creutzfeldt-Jakob in humans, BSE (bovine spongiform encephalopathy) in cattle and scrapie in sheep are so-called prion diseases, whereby one of the body's normal proteins, the prion protein PrPc misfolds into a pathogenic form: PrPSc. In spite of several years of extensive research, little is still known about what actually happens in this process...
ProMetic Life Sciences Inc./vCJD Infection: A Continuing Threat To Public Health published
Thu, 04 Feb 2010 10:00:00 PDT
Variant Creutzfeldt-Jakob Disease ("vCJD") remains 'a very real and continuing threat to public health and recent developments strongly support predictions of second and third waves of long incubation vCJD' commented Dr Robert Rohwer, Director, Molecular Neurovirology Laboratory and Associate Professor of Neurology, University of Maryland, Baltimore, U.S...
'Lifeless' Prions Capable Of Evolutionary Change And Adaptation Shown By Scripps Florida Scientists published
Mon, 04 Jan 2010 01:00:00 PDT
Scientists from The Scripps Research Institute have determined for the first time that prions, bits of infectious protein devoid of DNA or RNA that can cause fatal neurodegenerative disease, are capable of Darwinian evolution...
SaBTO Recommends Use Of P-Capt(R) Prion Reduction Filter To Protect Children From VCJD Blood Transmission published
Mon, 23 Nov 2009 03:00:00 PDT
ProMetic Life Sciences Inc. (TSX:PLI) ("ProMetic") and MacoPharma SA ("MacoPharma") announce that the Advisory Committee on the Safety of Blood, Tissues and Organs ("SaBTO"), an independent Committee that advises the UK Department of Health ("DoH"), has recommended the adoption of the P-Capt® prion reduction filter to pre-treat red blood cells destined for children born since 1 January 1996...
Researchers Find New Piece Of BSE Puzzle published
Sun, 22 Nov 2009 00:00:00 PDT
A new treatment route for bovine spongiform encephalopathy (BSE) and its human form Creutzfeldt Jakob disease (CJD) could be a step closer based on new results from scientists at the University of Leeds. The team has found that a protein called Glypican-1 plays a key role in the development of BSE...
Leeds Research Finds New Piece Of BSE Puzzle published
Fri, 20 Nov 2009 12:00:00 PDT
New research funded mainly through the Wellcome Trust with additional support from the Medical Research Council shows that a new treatment route for bovine spongiform encephalopathy (BSE) and its human form Creutzfeldt Jakob disease (CJD) could be a step closer. The research carried out by scientists at the University of Leeds was published today (November 20) in PLoS Pathogens...
Brain Disease "Resistance Gene" Could Offer Insights Into CJD published
Fri, 20 Nov 2009 11:00:00 PDT
A community in Papua New Guinea that suffered a major epidemic of a CJD-like fatal brain disease called kuru has developed strong genetic resistance to the disease, according to new research by Medical Research Council (MRC) scientists. Kuru is a fatal prion disease, similar to CJD in humans and BSE in animals, and is geographically unique to an area in Papua New Guinea...
The Protein Srebp2 Drives Cholesterol Formation In Prion-Infected Neuronal Cells Which May Promote Prion-Dependent Diseases published
Thu, 19 Nov 2009 05:00:00 PDT
Prions are causing fatal and infectious diseases of the nervous system, such as the mad cow disease (BSE), scrapie in sheep or Creutzfeldt-Jakob disease in humans...
Why Younger People Are More At Risk Of vCJD published
Thu, 15 Oct 2009 04:00:00 PDT
Specific cells within the immune system could help explain why younger people are more susceptible to variant CJD, scientists believe. Patients diagnosed with variant CJD are, on average, 28 years old but it has been unclear why older people are not as affected by the disease...
First Direct Information About The Prion's Molecular Structure Reported published
Tue, 06 Oct 2009 01:00:00 PDT
A collaboration between scientists at Vanderbilt University and the University of California, San Francisco has led to the first direct information about the molecular structure of prions. In addition, the study has revealed surprisingly large structural differences between natural prions and the closest synthetic analogs that scientists have created in the lab...
Gene Mutation Alone Causes Transmissible Prion Disease published
Thu, 27 Aug 2009 03:00:00 PDT
For the first time, Whitehead Institute researchers have shown definitively that mutations associated with prion diseases are sufficient to cause a transmissible neurodegenerative disease. The discovery is reported in the August 27 edition of the journal Neuron. Until now, two theories about the role mutations play in prion diseases have been at odds...
Impaired Transport In Neurons Triggers Prion Disease published
Tue, 25 Aug 2009 00:00:00 PDT
A new study shows that nervous system integrity and axonal properties may play a key role in prion diseases. The findings, from researchers at the Rudolf Virchow Center and the Institute of Virology of the University of Würzburg, expand our understanding of the development of prion disease and suggest novel targets for therapeutic and diagnostic approaches in its early stages...
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